Welcome to MINDS!
Established in 2020, POSTECH Mathematical Institute for Data Science (MINDS) is the community of researchers in the areas of fundamental data science, machine learning, artificial intelligence, scientific computing, and humanitarian data science. MINDS mission is to provide a platform for collaboration among researchers and to provide various opportunities for students in data science. MINDS also aims to use our data science research to serve our local and global communities pursuing humanitarian data science.
News
🌟 DACON Ranker Special Lecture: Winning Strategies for AI Competitions 🌟
2023.11.30
3nd POSTECH&Peking SIAM Student Chapter Joint Conference
2023.11.01
2023 PSSC Summer Camp
2023.10.04
[POSTECH(포항공과대학교) 수리 데이터과학 연구소 연구계약직 공고]-상시모집
2023.07.25
[POSTECH(포항공과대학교) 수리 데이터과학 연구소 연구계약직 공고]
2023.07.14
[POSTECH(포항공과대학교) 수리 데이터과학 연구소 연구교수 채용 공고]
2023.06.12
Seminar | Joint seminar for probability and mathematical biology
2023.05.02
[POSTECH(포항공과대학교) 수리 데이터과학 연구소 연구계약직 공고]
2023.02.15
Upcoming Events
Schedule
MINDS SEMINAR
MINDS Seminar Series | Sun Young Shin (UT Dalla) - Scalable protein-DNA binding changer test for insertion and deletion of bases in the genome
MINDS SEMINAR
period : 2022-04-05 ~ 2022-04-05
time : 10:00:00 ~ 11:00:00
개최 장소 : Online streaming (Zoom)
Topic : Scalable protein-DNA binding changer test for insertion and deletion of bases in the genome
개요
Date | 2022-04-05 ~ 2022-04-05 | Time | 10:00:00 ~ 11:00:00 |
Speaker | Sun Young Shin | Affiliation | UT Dallas |
Place | Online streaming (Zoom) | Streaming link | ID : 688 896 1076 / PW : 54321 |
Topic | Scalable protein-DNA binding changer test for insertion and deletion of bases in the genome | ||
Contents | Mutations in the noncoding DNA, which represents approximately 99\% of the human genome, have been crucial to understand disease mechanisms through dysregulation of disease-associated genes. One key element in gene regulation that noncoding mutations mediate is the binding of proteins to DNA sequences. Insertion and deletion of bases (InDels) are the second most common type of mutations, following single nucleotide polymorphisms, that may impact protein-DNA binding. However, no existing methods can estimate and test the effects of InDels on the process of protein-DNA binding. We develop a novel statistical test, named binding changer test (BC test), using a Markov model to evaluate the impact of InDels and identify InDels altering protein-DNA binding. The test predicts binding changer InDels of regulatory significance with an efficient importance sampling algorithm generating background sequences in favor of large binding affinity changes. Simulation studies demonstrate its excellent performance. The application to human leukemia data uncovers candidate pathologic InDels on modulating MYC binding in leukemic patients. We develop R package atIndel, which is available on GitHub. |
POSTECH SIAM Student Chapter
🌟 DACON Ranker Special Lecture: Winning Strategies for AI Competitions 🌟
2023 POSTECH & Peking SIAM Student Chapter Joint Conference
2023 PSSC Summer Camp
2022 PSSC Summer Camp
2022 POSTECH & Peking SIAM Student Chapter Joint Conference
MINDS-MoNET-ISE Workshop
Information, Network & Topological Data Analysis
2021 POSTECH MINDS WORKSHOP
Recent Progress in Data Science and Applications
- Nov. 19(Fri) ~ Nov. 20(Sat) 2021 (1 Night 2 Days)
- Workshop homepage
Fall 2021 Seminar Series
MINDS Seminar Series on Data Science, Machine Learning, and Scientific Computing
Every Tuesdays 05:00 PM
ILJU POSTECH MINDS Workshop on TDA and ML
July 6 ~ July 9
Registration is required (please register here)