Welcome to MINDS!

Established in 2020, POSTECH Mathematical Institute for Data Science (MINDS) is the community of researchers in the areas of fundamental data science, machine learning, artificial intelligence, scientific computing, and humanitarian data science. MINDS mission is to provide a platform for collaboration among researchers and to provide various opportunities for students in data science. MINDS also aims to use our data science research to serve our local and global communities pursuing humanitarian data science.

News

🌟 DACON Ranker Special Lecture: Winning Strategies for AI Competitions 🌟 2023.11.30

3nd POSTECH&Peking SIAM Student Chapter Joint Conference 2023.11.01

2023 PSSC Summer Camp 2023.10.04

[POSTECH(포항공과대학교) 수리 데이터과학 연구소 연구계약직 공고]-상시모집 2023.07.25

[POSTECH(포항공과대학교) 수리 데이터과학 연구소 연구계약직 공고] 2023.07.14

[POSTECH(포항공과대학교) 수리 데이터과학 연구소 연구교수 채용 공고] 2023.06.12

Seminar | Joint seminar for probability and mathematical biology 2023.05.02

[POSTECH(포항공과대학교) 수리 데이터과학 연구소 연구계약직 공고] 2023.02.15

Upcoming Events

Schedule

MINDS SEMINAR

MINDS Seminar Series | Minjin Ha (Yonsei University) - BAYESIAN ROBUST LEARNING IN CHAIN GRAPH MODELS

MINDS SEMINAR

period : 2023-04-18 ~ 2023-04-18

time : 17:00:00 ~ 18:00

개최 장소 : Online streaming (Zoom)

Topic : BAYESIAN ROBUST LEARNING IN CHAIN GRAPH MODELS

개요

Date	2023-04-18 ~ 2023-04-18	Time	17:00:00 ~ 18:00
Speaker	Minjin Ha	Affiliation	Yonsei University
Place	Online streaming (Zoom)	Streaming link	ID : 688 896 1076 / PW : 54321
Topic	BAYESIAN ROBUST LEARNING IN CHAIN GRAPH MODELS
Contents	Integrative analysis of multi-level pharmacogenomic data for modeling dependencies across various biological domains is crucial for developing genomic-testing based treatments. Chain graphs characterize conditional dependence structures of such multi-level data where variables are naturally partitioned into multiple ordered layers, consisting of both directed and undirected edges. Existing literature mostly focus on Gaussian chain graphs, which are ill-suited for non-normal distributions with heavy-tailed marginals, potentially leading to inaccurate inferences. We propose a Bayesian robust chain graph model (RCGM) based on random transformations of marginals using Gaussian scale mixtures to account for node-level non-normality in continuous multivariate data. This flexible modeling strategy facilitates identification of conditional sign dependencies among non-normal nodes while still being able to infer conditional dependencies among normal nodes. In simulations, we demonstrate that RCGM outperforms existing Gaussian chain graph inference methods in data generated from various non-normal mechanisms. We apply our method to genomic, transcriptomic and proteomic data to understand underlying biological processes holistically for drug response and resistance in lung cancer cell lines. Our analysis reveals inter- and intra- platform dependencies of key signaling pathways to monotherapies of icotinib, erlotinib and osimertinib among other drugs, along with shared patterns of molecular mechanisms behind drug actions.